14-3-3 proteins regulate retinal axon growth by modulating ADF/cofilin activity
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چکیده
منابع مشابه
14-3-3 proteins regulate protein kinase a activity to modulate growth cone turning responses.
Growth cones regulate the speed and direction of neuronal outgrowth during development and regeneration. How the growth cone spatially and temporally regulates signals from guidance cues is poorly understood. Through a proteomic analysis of purified growth cones we identified isoforms of the 14-3-3 family of adaptor proteins as major constituents of the growth cone. Disruption of 14-3-3 via the...
متن کاملThe 14-3-3 proteins positively regulate rapamycin-sensitive signaling
BACKGROUND The kinase Tor is the target of the immunosuppressive drug rapamycin and is a member of the phosphatidylinositol kinase (PIK)-related kinase family. It plays an essential role in progression through the G1 phase of the cell cycle. The molecular details of Tor signaling remain obscure, however. RESULTS We isolated two Saccharomyces cerevisiae genes, BMH1 and BMH2, as multicopy suppr...
متن کامل14-3-3 proteins regulate Tctp-Rheb interaction for organ growth in Drosophila.
14-3-3 family proteins regulate multiple signalling pathways. Understanding biological functions of 14-3-3 proteins has been limited by the functional redundancy of conserved isotypes. Here we provide evidence that 14-3-3 proteins regulate two interacting components of Tor signalling in Drosophila, translationally controlled tumour protein (Tctp) and Rheb GTPase. Single knockdown of 14-3-3ɛ or ...
متن کامل14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening.
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common known cause of inherited Parkinson's disease (PD), and LRRK2 is a risk factor for idiopathic PD. How LRRK2 function is regulated is not well understood. Recently, the highly conserved 14-3-3 proteins, which play a key role in many cellular functions including cell death, have been shown to interact with LRRK2. In this study, ...
متن کاملThe 14-3-3 proteins
So what’s so interesting about them? In 1996 14-3-3 was found to bind to a variety of oncoproteins including Raf-1, polyoma middle T, and Bcr-Abl. Since then the 14-3-3 proteins have been shown to bind to a wide variety of proteins involved in signal transduction, cell cycle and apoptosis. These proteins include Cdc25, NFAT, Bad, Cbl, A20, PI 3-kinase, IRS-1, MEKK, p130Cas, glucocorticoid recep...
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ژورنال
عنوان ژورنال: Developmental Neurobiology
سال: 2012
ISSN: 1932-8451
DOI: 10.1002/dneu.20955